Structure of PDB 4xsv Chain A

Receptor sequence
>4xsvA (length=306) Species: 9606 (Homo sapiens) [Search protein sequence]
GRRAVRVWCDGCYDMVHYGHSNQLRQARAMGDYLIVGVHTDEEIAKHKGP
PVFTQEERYKMVQAIKWVDEVVPAAPYVTTLETLDKYNCDFCVHGNDITL
TVDGRDTYEEVKQAGRYRECKRTQGVSTTDLVGRMLLVTKWTGVSQFLQT
SQKIIQFASGKEPQPGETVIYVAGAFDLFHIGHVDFLEKVHRLAERPYII
AGLHFDQEVNHYKGKNYPIMNLHERTLSVLACRYVSEVVIGAPYAVTAEL
LSHFKVDLVCHGKTEIIPDRDGSDPYQEPKRRGIFRQIDSGSNLTTDLIV
QRIITN
3D structure
PDB4xsv Human CTP: Phosphoethanolamine Cytidylyltransferase
ChainA
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H65 G67
Catalytic site (residue number reindexed from 1) H47 G49
Enzyme Commision number 2.7.7.14: ethanolamine-phosphate cytidylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C5P A G220 A221 F222 H229 F232 H307 G308 T310 S336 L340 G174 A175 F176 H183 F186 H261 G262 T264 S290 L294
BS02 CTP A G29 C30 Y31 H35 H38 R140 T141 V144 S145 T146 G11 C12 Y13 H17 H20 R122 T123 V126 S127 T128
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004306 ethanolamine-phosphate cytidylyltransferase activity
Biological Process
GO:0006646 phosphatidylethanolamine biosynthetic process
GO:0009058 biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4xsv, PDBe:4xsv, PDBj:4xsv
PDBsum4xsv
PubMed
UniProtQ99447|PCY2_HUMAN Ethanolamine-phosphate cytidylyltransferase (Gene Name=PCYT2)

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