Structure of PDB 4xsc Chain A

Receptor sequence
>4xscA (length=263) Species: 341980 (Human herpesvirus 3 strain Oka vaccine) [Search protein sequence]
TLTGELQYLKQVDDILRYGVRKRDRTGIGTLSLFGMQARYNLRNEFPLLT
TKRVFWRAVVEELLWFIRGSTDSKELAAKDIHIWDTGDLGPIYGFQWRHF
GAEYKDCQSNYLQQGIDQLQTVIDTIKTNPESRRMIISSWNPKDIPLMVL
PPCHTLCQFYVANGELSCQVYQRSGDMGLGVPFNIAGYALLTYIVAHVTG
LKTGDLIHTMGDAHIYLNHIDALKVQLARSPKPFPCLKIIRNVTDINDFK
WDDFQLDGYNPHP
3D structure
PDB4xsc Structure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of Brivudine.
ChainA
Resolution2.901 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E75 W97 Y123 C183 R203 D206
Catalytic site (residue number reindexed from 1) E62 W84 Y93 C153 R173 D176
Enzyme Commision number 2.1.1.45: thymidylate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BVP A R38 Y123 C183 Q202 R203 S204 G205 D206 G210 N214 H244 Y246 R25 Y93 C153 Q172 R173 S174 G175 D176 G180 N184 H214 Y216
BS02 BVP A R163 R164 R133 R134
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0016741 transferase activity, transferring one-carbon groups
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4xsc, PDBe:4xsc, PDBj:4xsc
PDBsum4xsc
PubMed26630264
UniProtQ4JQW2|TYSY_VZVO Thymidylate synthase (Gene Name=ORF13)

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