Structure of PDB 4xrh Chain A

Receptor sequence
>4xrhA (length=243) Species: 9606 (Homo sapiens) [Search protein sequence]
PVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASLTTQQAIGLKHYSD
FLERMPREEATEIEQTVQKAAQAFNSGLLCVACGSYRRGKATCGDVDVLI
THPDGRSHRGIFSRLLDSLRQEGFLTDDLVSQEENGQQQKYLGVCRLPGP
GRRHRRLDIIVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSEHAL
STAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYREPAERDW
3D structure
PDB4xrh Structural Mechanism for the Fidelity Modulation of DNA Polymerase lambda
ChainA
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D427 D429 D490
Catalytic site (residue number reindexed from 1) D95 D97 D158
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D427 D429 D95 D97
BS02 TTP A R386 G416 S417 R420 G426 D427 D429 Y505 F506 T507 G508 A510 N513 R54 G84 S85 R88 G94 D95 D97 Y173 F174 T175 G176 A178 N181
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4xrh, PDBe:4xrh, PDBj:4xrh
PDBsum4xrh
PubMed26836966
UniProtQ9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

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