Structure of PDB 4xr2 Chain A

Receptor sequence

>4xr2A (length=305) Species: 83333 (Escherichia coli K-12) [Search protein sequence]

DLVDRLNTTFRQMEQELAIFAAHLEQHKLLVARVFSLPEVKKEDEHNPLN
RIEVKQHLGNDAQSLALRHFRHLFIQQQSENRSSKAAVRLPGVLCYQVDN
LSQAALVSHIQHINKLKTTFEHIVTVESELPTAARFEWVARHLPGLITLN
AYRTLTVLHDPATLRFGWANKHIIKNLHRDEVLAQLEKSLKSPRSVAPWT
REEWQRKLEREYQDIAALPQNAKLKIKRPVKVQPIARVWYKGDQKQVQHA
CPTPLIALINRDNGAGVPDVGELLNYDADNVQHRYKPQAQPLRLIIPRLH
LYVAD

3D structure

PDB

4xr2 Replisome speed determines the efficiency of the Tus-Ter replication termination barrier.

Chain

Resolution

2.35 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	S88 K89 T129 R139 L153 Y156 R169 A173 N174 K175 H176 I178 K179 N180 R241 W243 Q250 V285 H287 R288 Q294	S84 K85 T125 R135 L149 Y152 R165 A169 N170 K171 H172 I174 K175 N176 R237 W239 Q246 V281 H283 R284 Q290
BS02	dna	A	K89 A90 A91 R93 R157 T158 K175 S193 W208 R232 Q252 Y289 R302	K85 A86 A87 R89 R153 T154 K171 S189 W204 R228 Q248 Y285 R298

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0043565	sequence-specific DNA binding

	Biological Process
GO:0006260	DNA replication
GO:0006274	DNA replication termination
GO:0071807	replication fork arrest involved in DNA replication termination

	Cellular Component
GO:0005737	cytoplasm

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:4xr2, PDBe:4xr2, PDBj:4xr2
PDBsum	4xr2
PubMed	26322585
UniProt	P16525\|TUS_ECOLI DNA replication terminus site-binding protein (Gene Name=tus)

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