Structure of PDB 4xr0 Chain A

Receptor sequence

>4xr0A (length=308) Species: 83333 (Escherichia coli K-12) [Search protein sequence]

ARYDLVDRLNTTFRQMEQELAIFAAHLEQHKLLVARVFSLPEVKKEDEHN
PLNRIEVKQHLGNDAQSLALRHFRHLFIQQQSENRSSKAAVRLPGVLCYQ
VDNLSQAALVSHIQHINKLKTTFEHIVTVESELPTAARFEWVHRHLPGLI
TLNAYRTLTVLHDPATLRFGWANKHIIKNLHRDEVLAQLEKSLKSPRSVA
PWTREEWQRKLEREYQDIAALPQNAKLKIKRPVKVQPIARVWYKGDQKQV
QHACPTPLIALINRDNGAGVPDVGELLNYDADNVQHRYKPQAQPLRLIIP
RLHLYVAD

3D structure

PDB

4xr0 Replisome speed determines the efficiency of the Tus-Ter replication termination barrier.

Chain

Resolution

2.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	S88 K89 T129 F140 L153 R169 A173 N174 K175 H176 I178 K179 N180 R241 W243 Q250 V285 H287 R288 Q294	S87 K88 T128 F139 L152 R168 A172 N173 K174 H175 I177 K178 N179 R240 W242 Q249 V284 H286 R287 Q293
BS02	dna	A	H50 K89 A90 A91 R93 R157 T158 K175 S193 P197 R232 Q237 Q252 P256 Y289 R302	H49 K88 A89 A90 R92 R156 T157 K174 S192 P196 R231 Q236 Q251 P255 Y288 R301

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0043565	sequence-specific DNA binding

	Biological Process
GO:0006260	DNA replication
GO:0006274	DNA replication termination
GO:0071807	replication fork arrest involved in DNA replication termination

	Cellular Component
GO:0005737	cytoplasm

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:4xr0, PDBe:4xr0, PDBj:4xr0
PDBsum	4xr0
PubMed	26322585
UniProt	P16525\|TUS_ECOLI DNA replication terminus site-binding protein (Gene Name=tus)

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