Structure of PDB 4xqe Chain A

Receptor sequence

>4xqeA (length=474) Species: 1079 (Blastochloris viridis)

DWPVYHRIDGPIVMIGFGSIGRGTLPLIERHFAFDRSKLVVIDPSDEARK
LAEARGVRFIQQAVTRDNYRELLVPLLTAGPGQGFCVNLSVDTSSLDIME
LARENGALYIDTVVEPWLGFYFDPDLKPEARSNYALRETVLAARRNKPGG
TTAVSCCGANPGMVSWFVKQALVNLAADLGVTGEEPTTREEWARLAMDLG
VKGIHIAERDTQRASFPKPFDVFVNTWSVEGFVSEGLQPAELGWGTFERW
MPDNARGHDSGCGAGIYLLQPGANTRVRSWTPTAMAQYGFLVTSNESISI
ADFLTVRDAAGQAVYRPTCHYAYHPCNDAVLSLHEMFGSGKRQSDWRILD
ETEIVDGIDELGVLLYGHGKNAYWYGSQLSIEETRRIAPDQNATGLQVSS
AVLAGMVWALENPNAGIVEADDLDFRRCLEVQTPYLGPVVGVYTDWTPLA
GRPGLFPEDIDTSDPWQFRNVLVR

3D structure

• PDB: 4xqe Comprehensive Structural Characterization of the Bacterial Homospermidine Synthase-an Essential Enzyme of the Polyamine Metabolism.
• Chain: A
• Resolution: 1.3 Å

Enzymatic activity

• Enzyme Commision number: 2.5.1.44: homospermidine synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAD	A	G20 S21 I22 D45 P46 A65 V66 L91 S92 V93 T95 T114 G160 A161 N162 P163 W229 S230 V400	G18 S19 I20 D43 P44 A63 V64 L89 S90 V91 T93 T112 G158 A159 N160 P161 W227 S228 V398
BS02	1PS	A	S47 D48 E49 W348	S45 D46 E47 W346
BS03	AG2	A	N162 E210 W229 E237 S296 Y323	N160 E208 W227 E235 S294 Y321
BS04	AG2	A	R146 R191 D424	R144 R189 D422
BS05	1PS	A	G342 K343	G340 K341

Gene Ontology

Molecular Function

• GO:0016740 transferase activity
• GO:0047296 homospermidine synthase activity
• GO:0050514 homospermidine synthase (spermidine-specific) activity

External links

• PDB: RCSB:4xqe, PDBe:4xqe, PDBj:4xqe
• PDBsum: 4xqe
• PubMed: 26776105
• UniProt: O32323|HSS_BLAVI Homospermidine synthase (Gene Name=hss)