Structure of PDB 4xqc Chain A

Receptor sequence

>4xqcA (length=475) Species: 1079 (Blastochloris viridis)

DWPVYHRIDGPIVMIGFGSIGRGTLPLIERHFAFDRSKLVVIDPSDEARK
LAEARGVRFIQQAVTRDNYRELLVPLLTAGPGQGFCVNLSVDTSSLDIME
LARENGALYIDTVVEPWLGFYFDPDLKPEARSNYALRETVLAARRNKPGG
TTAVSCCGANPGMVSWFVKQALVNLAADLGVTGEEPTTREEWARLAMDLG
VKGIHIAERDTQRASFPKPFDVFVNTWSVEGFVSEGLQPAELGWGTFERW
MPDNARGHDSGCGAGIYLLQPGANTRVRSWTPTAMAQYGFLVTHNESISI
ADFLTVRDAAGQAVYRPTCHYAYHPCNDAVLSLHEMFGSGKRQSDWRILD
ETEIVDGIDELGVLLYGHGKNAYWYGSQLSIEETRRIAPDQNATGLQVSS
AVLAGMVWALENPNAGIVEADDLDFRRCLEVQTPYLGPVVGVYTDWTPLA
GRPGLFPEDIDTSDPWQFRNVLVRD

3D structure

• PDB: 4xqc Comprehensive Structural Characterization of the Bacterial Homospermidine Synthase-an Essential Enzyme of the Polyamine Metabolism.
• Chain: A
• Resolution: 1.27 Å

Enzymatic activity

• Enzyme Commision number: 2.5.1.44: homospermidine synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAD	A	G20 S21 I22 D45 P46 A65 V66 S92 V93 T95 T114 G160 A161 N162 P163 W229 S230 V400	G18 S19 I20 D43 P44 A63 V64 S90 V91 T93 T112 G158 A159 N160 P161 W227 S228 V398
BS02	13D	A	N162 W229 E237 H296	N160 W227 E235 H294
BS03	13D	A	V93 E117 E232 G233 S236	V91 E115 E230 G231 S234
BS04	1PS	A	F124 G342 K343 R344	F122 G340 K341 R342

Gene Ontology

Molecular Function

• GO:0016740 transferase activity
• GO:0047296 homospermidine synthase activity
• GO:0050514 homospermidine synthase (spermidine-specific) activity

External links

• PDB: RCSB:4xqc, PDBe:4xqc, PDBj:4xqc
• PDBsum: 4xqc
• PubMed: 26776105
• UniProt: O32323|HSS_BLAVI Homospermidine synthase (Gene Name=hss)