Structure of PDB 4xq6 Chain A

Receptor sequence
>4xq6A (length=317) Species: 419947 (Mycobacterium tuberculosis H37Ra) [Search protein sequence]
VAPVRRLLRRLLGPTDPVLASTVFGVRFPAPLGLAAGFDKDGTALSSWGA
MGFGYAEIGTVTAHPQPLFRLADDRALLNRMGFNNHGARALAIRLARHRP
EIPIGVNIGKTKKTPAGDAVNDYRASARMVGPLASYLVVNVSSPNTPGLR
DLQAVESLRPILSAVRAETSTPVLVKIAPDLSDSDLDDIADLAVELDLAG
IVATNTTVSRDGLTTPGVDRLGPGGISGPPLAQRAVQVLRRLYDRVGDRL
ALISVGGIETADDAWERITAGASLLQGYTGFIYGGERWAKDIHEGIARRL
HDGGFGSLHEAVGSARR
3D structure
PDB4xq6 Crystal structure of Dihydroorotate Dehydrogenase form Mycobacterium Tuberculosis
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N115 F119 S179 N181 T182 K212 N241
Catalytic site (residue number reindexed from 1) N79 F83 S143 N145 T146 K176 N205
Enzyme Commision number 1.3.5.2: dihydroorotate dehydrogenase (quinone).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FMN A A66 G67 T90 N115 N176 K212 N241 S263 G264 V291 G292 G293 G313 Y314 T315 A36 G37 T60 N79 N140 K176 N205 S227 G228 V255 G256 G257 G277 Y278 T279
Gene Ontology
Molecular Function
GO:0004152 dihydroorotate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0106430 dihydroorotate dehydrogenase (quinone) activity
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006222 UMP biosynthetic process
GO:0009220 pyrimidine ribonucleotide biosynthetic process
GO:0044205 'de novo' UMP biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:4xq6, PDBe:4xq6, PDBj:4xq6
PDBsum4xq6
PubMed
UniProtP9WHL1|PYRD_MYCTU Dihydroorotate dehydrogenase (quinone) (Gene Name=pyrD)

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