Structure of PDB 4xpt Chain A

Receptor sequence

>4xptA (length=535) Species: 7227 (Drosophila melanogaster)

DERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLA
VGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVGFYY
NVIIAWSLRFFFASFTNSLPWTSCNNIWNTPNCRPFEVGHVEGFQSAASE
YFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKV
VWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAA
TQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIF
SVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWALIFFMML
ATLGLDSSFGGMEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLASCT
QGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFP
PGRYWQVCWRFVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIA
GSSVVMIPAVAIFKLLSTPGSLRQRFTILTTPWRD

3D structure

• PDB: 4xpt Neurotransmitter and psychostimulant recognition by the dopamine transporter.
• Chain: A
• Resolution: 3.36 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	BGC	A	D312 Y481	D248 Y417
BS02	GLC	A	G480 Y481 G538	G416 Y417 G474
BS03	Y01	A	A74 Y342 Y518 W519	A50 Y278 Y454 W455
BS04	42J	A	F43 D46 A117 V120 F319 F325 S421	F19 D22 A93 V96 F255 F261 S357
BS05	CLR	A	L37 L277	L13 L213
BS06	CL	A	Y69 S320 S356	Y45 S256 S292
BS07	NA	A	A44 D46 N49 S320 N352	A20 D22 N25 S256 N288
BS08	NA	A	G42 V45 D46 L417 D420 S421	G18 V21 D22 L353 D356 S357

Gene Ontology

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:4xpt, PDBe:4xpt, PDBj:4xpt
• PDBsum: 4xpt
• PubMed: 25970245
• UniProt: Q7K4Y6|DAT_DROME Sodium-dependent dopamine transporter (Gene Name=DAT)