Structure of PDB 4xph Chain A

Receptor sequence
>4xphA (length=534) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
DERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLA
VGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVGFYY
NVIIAWSLRFFFASFTNSLPWTSCNNIWNTPNCRPFEGHVEGFQSAASEY
FNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVV
WFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAAT
QVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFS
VLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWALIFFMMLA
TLGLDSSFGGMEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLASCTQ
GGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPP
GRYWQVCWRFVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAG
SSVVMIPAVAIFKLLSTPGSLRQRFTILTTPWRD
3D structure
PDB4xph Neurotransmitter and psychostimulant recognition by the dopamine transporter.
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BGC A R133 A137 R109 A113
BS02 42J A F43 D46 V120 Y124 F319 F325 F19 D22 V96 Y100 F254 F260
BS03 NA A A44 D46 N49 S320 N352 A20 D22 N25 S255 N287
BS04 NA A G42 F43 V45 D46 L417 D420 S421 G18 F19 V21 D22 L352 D355 S356
BS05 CL A S320 S356 S255 S291
BS06 CLR A A74 Y518 A50 Y453
BS07 CLR A L37 Y273 I351 L13 Y208 I286
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:4xph, PDBe:4xph, PDBj:4xph
PDBsum4xph
PubMed25970245
UniProtQ7K4Y6|DAT_DROME Sodium-dependent dopamine transporter (Gene Name=DAT)

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