Structure of PDB 4xpg Chain A

Receptor sequence
>4xpgA (length=533) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
DERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLA
VGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVGFYY
NVIIAWSLRFFFASFTNSLPWTSCNNIWNTPNCRPFESQGFQSAASEYFN
RYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWF
TALFPYAALLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWADAATQV
FFSLGPGFGVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVL
GYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWALIFFMMLATL
GLDSSFGGMEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLASCTQGG
FYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGR
YWQVCWRFVAPIFLLFITVYLLIGYEPLTYADYVYPSWANALGWCIAGSS
VVMIPAVAIFKLLSTPGSLRQRFTILTTPWRDQ
3D structure
PDB4xpg Neurotransmitter and psychostimulant recognition by the dopamine transporter.
ChainA
Resolution3.21 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 42L A F43 D46 V120 F319 F325 G425 F19 D22 V96 F252 F258 G358
BS02 CLR A Y273 L277 I351 Y206 L210 I284
BS03 CL A Y69 S320 S356 Y45 S253 S289
BS04 NA A A44 D46 N49 S320 N352 A20 D22 N25 S253 N285
BS05 NA A G42 F43 V45 L417 G418 D420 S421 G18 F19 V21 L350 G351 D353 S354
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:4xpg, PDBe:4xpg, PDBj:4xpg
PDBsum4xpg
PubMed25970245
UniProtQ7K4Y6|DAT_DROME Sodium-dependent dopamine transporter (Gene Name=DAT)

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