Structure of PDB 4xpf Chain A

Receptor sequence
>4xpfA (length=532) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
DERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLA
VGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVGFYY
NVIIAWSLRFFFASFTNSLPWTSCNNIWNTPNCRPFESQGFQSAASEYFN
RYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWF
TALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQV
FFSLGPGFGVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVL
GYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWALIFFMMLATL
GLDSSFGGMEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLASCTQGG
FYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGR
YWQVCWRFVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAGSS
VVMIPAVAIFKLLSTPGSLRQRFTILTTPWRD
3D structure
PDB4xpf Neurotransmitter and psychostimulant recognition by the dopamine transporter.
ChainA
Resolution3.273 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DMU A R133 F136 Y219 D238 R109 F112 Y152 D171
BS02 42F A F43 D46 V120 G121 Y124 F325 F19 D22 V96 G97 Y100 F258
BS03 CLR A Y273 L277 I351 Y206 L210 I284
BS04 NA A A44 N49 S320 N352 A20 N25 S253 N285
BS05 NA A G42 F43 V45 D46 L417 G418 D420 S421 G18 F19 V21 D22 L350 G351 D353 S354
BS06 CL A Y69 S320 S356 Y45 S253 S289
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:4xpf, PDBe:4xpf, PDBj:4xpf
PDBsum4xpf
PubMed25970245
UniProtQ7K4Y6|DAT_DROME Sodium-dependent dopamine transporter (Gene Name=DAT)

[Back to BioLiP]