Structure of PDB 4xpb Chain A

Receptor sequence

>4xpbA (length=532) Species: 7227 (Drosophila melanogaster)

DERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLA
VGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVGFYY
NVIIAWSLRFFFASFTNSLPWTSCNNIWNTPNCRPFESQGFQSAASEYFN
RYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWF
TALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQV
FFSLGPGFGVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVL
GYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWALIFFMMLATL
GLDSSFGGMEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLASCTQGG
FYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGR
YWQVCWRFVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAGSS
VVMIPAVAIFKLLSTPGSLRQRFTILTTPWRD

3D structure

• PDB: 4xpb Neurotransmitter and psychostimulant recognition by the dopamine transporter.
• Chain: A
• Resolution: 3.05 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	BGC	A	R133 F136 Y219	R109 F112 Y152
BS02	NA	A	A44 V45 N49 S320 N352	A20 V21 N25 S253 N285
BS03	COC	A	F43 A44 D46 V120 Y124 F319 S320 G322 F325 S421 G425	F19 A20 D22 V96 Y100 F252 S253 G255 F258 S354 G358
BS04	CLR	A	V34 Y273	V10 Y206
BS05	CLR	A	Y518 W519	Y451 W452
BS06	NA	A	G42 F43 V45 D46 L417 D420 S421	G18 F19 V21 D22 L350 D353 S354
BS07	CL	A	S320 S356	S253 S289

Gene Ontology

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:4xpb, PDBe:4xpb, PDBj:4xpb
• PDBsum: 4xpb
• PubMed: 25970245
• UniProt: Q7K4Y6|DAT_DROME Sodium-dependent dopamine transporter (Gene Name=DAT)