Structure of PDB 4xpa Chain A

Receptor sequence

>4xpaA (length=534) Species: 7227 (Drosophila melanogaster)

DERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLA
VGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYY
NVIIAWSLRFFFASFTNSLPWTSCNNIWNTPNCRPFEGHVEGFQSAASEY
FNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVV
WFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAAT
QVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFS
VLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWALIFFMMLA
TLGLDSSFGGSEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLASCTQ
GGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPP
GRYWQVCWRFVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAG
SSVVMIPAVAIFKLLSTPGSLRQRFTILTTPWRD

3D structure

• PDB: 4xpa Neurotransmitter and psychostimulant recognition by the dopamine transporter.
• Chain: A
• Resolution: 2.95 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	BGC	A	R133 A137	R109 A113
BS02	CLR	A	Y273 I351	Y208 I286
BS03	CLR	A	A74 F357 Y518 W519	A50 F292 Y453 W454
BS04	42J	A	F43 D46 V120 F319 F325 S421	F19 D22 V96 F254 F260 S356
BS05	CL	A	S320 S356	S255 S291
BS06	NA	A	A44 V45 D46 N49 S320 N352	A20 V21 D22 N25 S255 N287
BS07	NA	A	G42 F43 V45 L417 G418 D420 S421	G18 F19 V21 L352 G353 D355 S356

Gene Ontology

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:4xpa, PDBe:4xpa, PDBj:4xpa
• PDBsum: 4xpa
• PubMed: 25970245
• UniProt: Q7K4Y6|DAT_DROME Sodium-dependent dopamine transporter (Gene Name=DAT)