Structure of PDB 4xp5 Chain A

Receptor sequence

>4xp5A (length=534) Species: 7227 (Drosophila melanogaster)

DERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLA
VGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYY
NVIIAWSLRFFFASFTNSLPWTSCNNIWNTPNCRPFEGHVEGFQSAASEY
FNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVV
WFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAAT
QVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFS
VLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWALIFFMMLA
TLGLDSSFGGSEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLASCTQ
GGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPP
GRYWQVCWRFVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAG
SSVVMIPAVAIFKLLSTPGSLRQRFTILTTPWRD

3D structure

• PDB: 4xp5 Neurotransmitter and psychostimulant recognition by the dopamine transporter.
• Chain: A
• Resolution: 3.3 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GLC	A	A137 Y219	A113 Y154
BS02	GLC	A	R133 F136	R109 F112
BS03	42F	A	F43 D46 V120 D121 Y124 F319 S320 F325 G425	F19 D22 V96 D97 Y100 F254 S255 F260 G360
BS04	CLR	A	L73 A74 Y518 W519	L49 A50 Y453 W454
BS05	CLR	A	L37 L38 Y273 I351	L13 L14 Y208 I286
BS06	NA	A	A44 N49 S320 N352	A20 N25 S255 N287
BS07	CL	A	S320 S356	S255 S291
BS08	NA	A	G42 V45 D46 L417 D420 S421	G18 V21 D22 L352 D355 S356

Gene Ontology

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:4xp5, PDBe:4xp5, PDBj:4xp5
• PDBsum: 4xp5
• PubMed: 25970245
• UniProt: Q7K4Y6|DAT_DROME Sodium-dependent dopamine transporter (Gene Name=DAT)