Structure of PDB 4xp4 Chain A

Receptor sequence
>4xp4A (length=534) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
DERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLA
VGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYY
NVIIAWSLRFFFASFTNSLPWTSCNNIWNTPNCRPFEGHVEGFQSAASEY
FNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVV
WFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAAT
QVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFS
VLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWALIFFMMLA
TLGLDSSFGGSEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLASCTQ
GGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPP
GRYWQVCWRFVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAG
SSVVMIPAVAIFKLLSTPGSLRQRFTILTTPWRD
3D structure
PDB4xp4 Neurotransmitter and psychostimulant recognition by the dopamine transporter.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y01 A L73 I78 Y518 W519 L49 I54 Y453 W454
BS02 COC A F43 D46 V120 D121 Y124 F319 S320 F325 S421 G425 F19 D22 V96 D97 Y100 F254 S255 F260 S356 G360
BS03 NA A A44 N49 S320 N352 A20 N25 S255 N287
BS04 NA A G42 F43 V45 D46 L417 G418 D420 S421 G18 F19 V21 D22 L352 G353 D355 S356
BS05 CL A S320 S356 S255 S291
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:4xp4, PDBe:4xp4, PDBj:4xp4
PDBsum4xp4
PubMed25970245
UniProtQ7K4Y6|DAT_DROME Sodium-dependent dopamine transporter (Gene Name=DAT)

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