Structure of PDB 4xm8 Chain A

Receptor sequence
>4xm8A (length=500) Species: 1392 (Bacillus anthracis) [Search protein sequence]
SRYEKWEKIKQHYQHWSDSLSEEGRGLLKKLQIPIEPKKDDIIHSLSQEE
KELLKRIQIDSSSTEEKEFLKKLQIDIRDSLSEEEKELLNPLSEKEKEFL
KKLKLDIQPYDINQRLQDTGGLIDSPSINLDVRKQYKRDIQNIDALLHQS
IGSTLYNKIYLYENMNINNLTATLGADLVDSTDNTKINRGIFNEFKKNFK
YSISSNYMIVDINERPALDNERLKWRIQLSPDTRAGYLENGKLILQRNIG
LEIKDVQIIKQSEKEYIRIDAKVVPKSKIDTKIQEAQLNINQEWNKALGL
PKYTKLITFNVHNRYASNIVESAYLILNEWKNNIQSDLIKKVTNYLVDGN
GRFVFTDITLPNIAEQYTHQDEIYEQVHSKGLYVPESRSILLHGPSKGVE
LRNDSEGFIHEFGHAVDDYAGYLLDKNQSDLVTNSKKFIDIFKEEGSNLT
SYGRTNEAEFFAEAFRLMHSTDHAERLKVQKNAPKTFQFINDQIKFIINS
3D structure
PDB4xm8 Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor.
ChainA
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H686 E687 H690 Y728 E735
Catalytic site (residue number reindexed from 1) H410 E411 H414 Y452 E459
Enzyme Commision number 3.4.24.83: anthrax lethal factor endopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 41T A S655 K656 G657 G674 V675 L677 N679 G683 H686 E687 H690 Y728 E735 S379 K380 G381 G398 V399 L401 N403 G407 H410 E411 H414 Y452 E459 PDBbind-CN: -logKd/Ki=3.02,IC50=950uM
BS02 ZN A H686 H690 E735 H410 H414 E459
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity

View graph for
Molecular Function
External links
PDB RCSB:4xm8, PDBe:4xm8, PDBj:4xm8
PDBsum4xm8
PubMed26578066
UniProtP15917|LEF_BACAN Lethal factor (Gene Name=lef)

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