Structure of PDB 4xm7 Chain A

Receptor sequence
>4xm7A (length=510) Species: 1392 (Bacillus anthracis) [Search protein sequence]
LSRYEKWEKIKQHYQHWSDSLSEEGRGLLKKLQIPIEPKKDDIIHSLSQE
EKELLKRIQIDSSDFLSTEEKEFLKKLQIDIRDEEEKELLNRIQVDSSNP
LSEKEKEFLKKLKLDIQPYDINQRLQDTGGLIDSPSINLDVRKQYKRDIQ
NIDALLHQSIGSTLYNKIYLYENMNINNLTATLGADLVDSTDNTKINRGI
FNEFKKNFKYSISSNYMIVDINERPALDNERLKWRIQLSPDTRAGYLENG
KLILQRNIGLEIKDVQIIKQSEKEYIRIDAKVVPKSKIDTKIQEAQLNIN
QEWNKALGLPKYTKLITFNVHNRYASNIVESAYLILNEWKNNIQSDLIKK
VTNYLVDGNGRFVFTDITLPNIAEQYTHQDEIYEQVHSKGLYVPESRSIL
LHGPSKGVELRNDSEGFIHEFGHAVDDYAGYLLDKNQSDLVTNSKKFIDI
FKEEGSNLTSYGRTNEAEFFAEAFRLMHSTDHAERLKVQKNAPKTFQFIN
DQIKFIINSL
3D structure
PDB4xm7 Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor.
ChainA
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H686 E687 H690 Y728 E735
Catalytic site (residue number reindexed from 1) H419 E420 H423 Y461 E468
Enzyme Commision number 3.4.24.83: anthrax lethal factor endopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 41S A S655 K656 G657 L668 L677 G683 H686 E687 H690 Y728 S388 K389 G390 L401 L410 G416 H419 E420 H423 Y461 PDBbind-CN: -logKd/Ki=3.57,IC50=267uM
BS02 ZN A H686 H690 E735 H419 H423 E468
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity

View graph for
Molecular Function
External links
PDB RCSB:4xm7, PDBe:4xm7, PDBj:4xm7
PDBsum4xm7
PubMed26578066
UniProtP15917|LEF_BACAN Lethal factor (Gene Name=lef)

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