Structure of PDB 4xm6 Chain A

Receptor sequence
>4xm6A (length=486) Species: 1392 (Bacillus anthracis) [Search protein sequence]
SRYEKWEKIKQHYQHWSDSLSEEGRGLLKKLQIPIEPKKDDIIHSLSQEE
KELLKRIQIDSSLSTEEKEFLKKLQIDLSEKEKEFLKKLKLDIQPYDINQ
RLQDTGGLIDSPSINLDVRKQYKRDIQNIDALLHQSIGSTLYNKIYLYEN
MNINNLTATLGADLVDSTDNTKINRGIFNEFKKNFKYSISSNYMIVDINE
RPALDNERLKWRIQLSPDTRAGYLENGKLILQRNIGLEIKDVQIIKQSEK
EYIRIDAKVVPKSKIDTKIQEAQLNINQEWNKALGLPKYTKLITFNVHNR
YASNIVESAYLILNEWKNNIQSDLIKKVTNYLVDGNGRFVFTDITLPNIA
EQYTHQDEIYEQVHSKGLYVPESRSILLHGPSKGVELRNDSEGFIHEFGH
AVDDYAGYLLDKNQSDLVTNSKKFIDIFKEEGSNLTSYGRTNEAEFFAEA
FRLMHSTDHAERLKVQKNAPKTFQFINDQIKFIINS
3D structure
PDB4xm6 Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor.
ChainA
Resolution2.352 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H686 E687 H690 Y728 E735
Catalytic site (residue number reindexed from 1) H396 E397 H400 Y438 E445
Enzyme Commision number 3.4.24.83: anthrax lethal factor endopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 41R A K656 G657 L668 G674 V675 L677 G683 H686 E687 Y728 E735 K366 G367 L378 G384 V385 L387 G393 H396 E397 Y438 E445 MOAD: ic50=90uM
PDBbind-CN: -logKd/Ki=4.05,IC50=90uM
BS02 ZN A H686 H690 E735 H396 H400 E445
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity

View graph for
Molecular Function
External links
PDB RCSB:4xm6, PDBe:4xm6, PDBj:4xm6
PDBsum4xm6
PubMed26578066
UniProtP15917|LEF_BACAN Lethal factor (Gene Name=lef)

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