Structure of PDB 4xlo Chain A

Receptor sequence
>4xloA (length=458) Species: 115828 (Streptomyces maritimus) [Search protein sequence]
QLDPATLAAFSAAFRGELIWPSDADYDEARRIWNGTIDRRPALIARCTST
PDVVAAVSFARKSGLLVAVRGGGHSMAGHSVCDGGIVIDLSLMNSIKVSR
RLRRARAQGGCLLGAFDTATQAHMLATPAGVVSHTGLGGLVLGGGFGWLS
RKYGLSIDNLTSVEIVTADGGVLTASDTENPDLFWAVRGGGGNFGVVTAF
EFDLHRVGPVRFASTYYSLDEGPQVIRAWRDHMATAPDELTWALYLRLAP
PLPELPADMHGKPVICAMSCWIGDPHEGERQLESILHAGKPHGLTKATLP
YRALQAYSFPGAVVPDRIYTKSGYLNELSDEATDTVLEHAADIASPFTQL
ELLYLGGAVARVPDDATAYPNRQSPFVTNLAAAWMDPTEDARHTAWAREG
YRALAGHLSGGYVNFMNPGEADRTREAYGAAKFERLQGVKAKYDPTNLFR
LNQNIPPS
3D structure
PDB4xlo Flavin-mediated dual oxidation controls an enzymatic Favorskii-type rearrangement.
ChainA
Resolution1.67 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H78 S137 T245
Catalytic site (residue number reindexed from 1) H74 S133 T241
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A W37 V73 R74 G75 G76 G77 H78 S79 M80 S84 L94 G113 G134 V135 V136 G140 G142 G143 L144 L146 F150 V200 V201 Y416 N418 L455 N456 W33 V69 R70 G71 G72 G73 H74 S75 M76 S80 L90 G109 G130 V131 V132 G136 G138 G139 L140 L142 F146 V196 V197 Y412 N414 L451 N452
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
GO:0050660 flavin adenine dinucleotide binding
GO:0071949 FAD binding

View graph for
Molecular Function
External links
PDB RCSB:4xlo, PDBe:4xlo, PDBj:4xlo
PDBsum4xlo
PubMed24162851
UniProtQ9KHK2

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