Structure of PDB 4xjr Chain A

Receptor sequence
>4xjrA (length=429) Species: 11216 (Human respirovirus 3) [Search protein sequence]
RITHDVGIKPLNPDDFWRCTSGLPSLMKTPKIRLMPGPGLLAMPTTVDGC
VRTPSLVINDLIYAYTSNLITRGCQDIGKSYQVLQIGIITVNVPDLNPRI
SHTFNINDNRKSCSLALLNTDVYQLCSTPKVDERSDYASSGIEDIVLDIV
NHDGSISTTRFKNNNISFDQPYAALYPSVGPGIYYKGKIIFLGYGGLEHP
INENAICNTTGCPGKTQRDCNQASHSPWFSDRRMVNSIIVVDKGLNSIPK
LKVWTISMRQNYWGSEGRLLLLGNKIYIYTRSTSWHSKLQLGIIDITDYS
DIRIKWTWHNVLSRPGNNECPWGHSCPDGCITGVYTDAYPLNPTGSIVSS
VILDSQKSRVNPVITYSTATERVNELAIRNKTLSAGYTTTSCITHYNKGY
CFHIVEINHKSLDTFQPMLFKTEIPKSCS
3D structure
PDB4xjr The catalytic mechanism of human parainfluenza virus type 3 haemagglutinin-neuraminidase revealed.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D279 S282 G284 A316 D136 S139 G141 A173
BS02 OEL A R192 T193 E276 Y319 Y337 E409 R424 R502 Y530 R52 T53 E133 Y176 Y194 E266 R281 R359 Y387 PDBbind-CN: -logKd/Ki=5.32,IC50=4.8uM
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
GO:0046789 host cell surface receptor binding
Biological Process
GO:0019058 viral life cycle
Cellular Component
GO:0019031 viral envelope

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4xjr, PDBe:4xjr, PDBj:4xjr
PDBsum4xjr
PubMed25676091
UniProtP08492|HN_PI3H4 Hemagglutinin-neuraminidase (Gene Name=HN)

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