Structure of PDB 4xj4 Chain A

Receptor sequence
>4xj4A (length=372) Species: 243277 (Vibrio cholerae O1 biovar El Tor str. N16961) [Search protein sequence]
RMTWNFHQYYTNRNDGLMGKLVLTDEEKNNLKALRKIIRLRTRDVFEEAK
GIAKAVKKSALTFEIIQEKVSTTQIKHLSDSEQREVAKLIYEMDDDARDE
FLGLTPRFWTQGSFQYDTLNRPFQPGQEMDIDDGTYMPMPIFESEPKIGH
SLLILLVDASLKSLVAENHGWKFEAKQTCGRIKIEAEKTHIDVPMYAIPK
DSENVNLALREGDRKWINSDPKIVEDWFNDSCIRIGKHLRKVCRFMKAWR
DAQWDVGGPSSISLMAATVNILDSVAHDASDLGETMKIIAKHLPSEFARG
VESPDSTDEKPLFPPSYKHGPREMDIMSKLERLPEILSSAESADSKSEAL
KKINMAFGNRVTNSELIVLAKA
3D structure
PDB4xj4 Structural Basis for the Catalytic Mechanism of DncV, Bacterial Homolog of Cyclic GMP-AMP Synthase
ChainA
Resolution1.596 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3AT A Q112 G113 S114 Y117 D133 K287 S301 L352 Q111 G112 S113 Y116 D132 K247 S261 L312
BS02 3AT A Q112 K177 T179 S259 Q111 K176 T178 S219
BS03 MG A D131 D133 D130 D132
Gene Ontology
Molecular Function
GO:0140701 3',3'-cyclic GMP-AMP synthase activity

View graph for
Molecular Function
External links
PDB RCSB:4xj4, PDBe:4xj4, PDBj:4xj4
PDBsum4xj4
PubMed25865248
UniProtQ9KVG7|DNCV_VIBCH Cyclic GMP-AMP synthase (Gene Name=dncV)

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