Structure of PDB 4xj3 Chain A

Receptor sequence
>4xj3A (length=369) Species: 243277 (Vibrio cholerae O1 biovar El Tor str. N16961) [Search protein sequence]
RMTWNFHQYYTNRNDGLMGKLVLTDEEKNNLKALRKIIRLRTRDVFEEAK
GIAKAVKKSALTFEIIQEKVSTTQIKHLSDSEQREVAKLIYEMDDDARDE
FLGLTPRFWTQGSFQYDTLNRPFQPGQEMDIDDGTYMPMPIFKIGHSLLI
LLVDASLKSLVAENHGWKFEAKQTCGRIKIEAEKTHIDVPMYAIPKDGSE
NVNLALREGDRKWINSDPKIVEDWFNDSCIRIGKHLRKVCRFMKAWRDAQ
WDVGGPSSISLMAATVNILDSVAHDASDLGETMKIIAKHLPSEFARGVES
PDSTDEKPLFPPSYKHGPREMDIMSKLERLPEILSSAESADSKSEALKKI
NMAFGNRVTNSELIVLAKA
3D structure
PDB4xj3 Structural Basis for the Catalytic Mechanism of DncV, Bacterial Homolog of Cyclic GMP-AMP Synthase
ChainA
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D131 D133 D130 D132
BS02 GTP A Q112 G113 S114 Y117 D133 K287 S301 D348 Q111 G112 S113 Y116 D132 K244 S258 D305
BS03 GTP A Q112 D133 K177 T179 C180 R182 D193 Y197 S259 Q111 D132 K172 T174 C175 R177 D188 Y192 S216
Gene Ontology
Molecular Function
GO:0140701 3',3'-cyclic GMP-AMP synthase activity

View graph for
Molecular Function
External links
PDB RCSB:4xj3, PDBe:4xj3, PDBj:4xj3
PDBsum4xj3
PubMed25865248
UniProtQ9KVG7|DNCV_VIBCH Cyclic GMP-AMP synthase (Gene Name=dncV)

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