Structure of PDB 4xi6 Chain A

Receptor sequence
>4xi6A (length=363) Species: 9606 (Homo sapiens) [Search protein sequence]
SRVMVEGVGARVVRGPDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGT
AANYRCSGAYDLRILDSAPTGIKHDGTMCDTCRQQPIIGIRWKCAECTNY
DLCTVCYHGDKHHLRHRFYRITTPGSERVLLESRRKSKKITARGIFAGAR
VVRGVDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDNGAKNLYR
VGFEGMSDLKCVQDAKGGSFYRDHCPVLGLVNIDLDLEIVQSLQHGHGGW
TDGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKASQFQVGD
LVQVCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDSDLKVEVCG
TSWTYNPAAVSKV
3D structure
PDB4xi6 A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb e3 ligases.
ChainA
Resolution2.04 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C85 C88 C109 C112 C79 C82 C103 C106
BS02 ZN A C100 C103 H118 H122 C94 C97 H112 H116
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0016567 protein ubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:4xi6, PDBe:4xi6, PDBj:4xi6
PDBsum4xi6
PubMed25747658
UniProtQ86YT6|MIB1_HUMAN E3 ubiquitin-protein ligase MIB1 (Gene Name=MIB1)

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