Structure of PDB 4xhl Chain A

Receptor sequence
>4xhlA (length=330) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
VGRKFRIGRKIGDIYHGTNLISGEEVAIRLESIRSRHPQLDYESRVYRYL
SGGVGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRRFSFKTVIMLA
LQMFCRIQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDF
NTHRHIPYRENKSLTGTARYASVNTHLGIEQSRRDDLESLGYVLIYFCKG
SLPWQGLKATTKKQKYDRIMEKKLNVSVETLCSGLPLEFQEYMAYCKNLK
FDEKPDYLFLARLFKDLSIKLEYHNDHLFDWTMLRYTKAMTFNKIKLLAM
KKFPTHFHYYKNEDKHNPSPEEIKQQTILN
3D structure
PDB4xhl Structure of the Saccharomyces cerevisiae Hrr25:Mam1 monopolin subcomplex reveals a novel kinase regulator.
ChainA
Resolution3.01 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CKI A I15 I23 A36 L85 D91 L135 I148 I11 I14 A27 L76 D82 L126 I139 PDBbind-CN: -logKd/Ki=4.43,IC50=37uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4xhl, PDBe:4xhl, PDBj:4xhl
PDBsum4xhl
PubMed27491543
UniProtP29295|HRR25_YEAST Casein kinase I homolog HRR25 (Gene Name=HRR25)

[Back to BioLiP]