Structure of PDB 4xhe Chain A

Receptor sequence
>4xheA (length=216) Species: 6500 (Aplysia californica) [Search protein sequence]
YKDDDDKLHSQANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVK
ADSSTNEVDLVYYEQQRWKLNSLMWDPNEYGNITDFRTSAADIWTPDITA
YSSTRPVQVLSPQIAVVTHDGSVMFIPAQRLSFMCDPTGVDSEEGATCAV
KFGSWVYSGFEIDLKTDTDQVDLSSYYASSKYEILSATQTRQVQHYSCCP
EPYIDVNLVVKFRERR
3D structure
PDB4xhe Marine Macrocyclic Imines, Pinnatoxins A and G: Structural Determinants and Functional Properties to Distinguish Neuronal alpha 7 from Muscle alpha 12 beta gamma delta nAChRs.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 40P A Y93 W147 V148 Y188 Y195 Y101 W155 V156 Y196 Y203 PDBbind-CN: -logKd/Ki=10.30,Kd<0.05nM
BS02 40P A T36 Y55 I118 T44 Y63 I126 PDBbind-CN: -logKd/Ki=10.30,Kd<0.05nM
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:4xhe, PDBe:4xhe, PDBj:4xhe
PDBsum4xhe
PubMed26004441
UniProtQ8WSF8

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