Structure of PDB 4xh4 Chain A

Receptor sequence
>4xh4A (length=394) Species: 99287 (Salmonella enterica subsp. enterica serovar Typhimurium str. LT2) [Search protein sequence]
FPVVLVINCGSSSIKFSVLDVATCDVLMAGIADGMNTENAFLSINGDKPI
NLAHSNYEDALKAIAFELEKRDLTDSVALIGHRIVHGGELFTQSVIITDE
IIDNIRRVSPLAPLHNYANLSGIDAARHLFPAVRQVAVFDTSFHQTLAPE
AYLYGLPWEYFSSLGVRRYGFHGTSHRYVSRRAYELLDLDEKDSGLIVAH
LGNGASICAVRNGQSVDTSMGMTPLEGLMMGTRSGDVDFGAMAWIAKETG
QTLSDLERVVNKESGLLGISGLSSDLRVLEKAWHEGHERARLAIKTFVHR
IARHIAGHAASLHRLDGIIFTGGIGENSVLIRQLVIEHLGVLGLTLDVEM
NKQPNSHGERIISANPSQVICAVIPTNEEKMIALDAIHLGNVKA
3D structure
PDB4xh4 Structures of substrate- and nucleotide-bound propionate kinase from Salmonella typhimurium: substrate specificity and phosphate-transfer mechanism
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) N11 R86 H175 R236 E381
Catalytic site (residue number reindexed from 1) N8 R83 H172 R233 E378
Enzyme Commision number 2.7.2.15: propionate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A H175 H203 G205 N206 G207 D278 L279 R280 G326 I327 N330 H172 H200 G202 N203 G204 D275 L276 R277 G323 I324 N327
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008776 acetate kinase activity
GO:0008980 propionate kinase activity
GO:0016301 kinase activity
GO:0016774 phosphotransferase activity, carboxyl group as acceptor
GO:0046872 metal ion binding
Biological Process
GO:0006082 organic acid metabolic process
GO:0006083 acetate metabolic process
GO:0016310 phosphorylation
GO:0070689 L-threonine catabolic process to propionate
Cellular Component
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4xh4, PDBe:4xh4, PDBj:4xh4
PDBsum4xh4
PubMed26249345
UniProtO06961|TDCD_SALTY Propionate kinase (Gene Name=tdcD)

[Back to BioLiP]