Structure of PDB 4xg8 Chain A

Receptor sequence
>4xg8A (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]
DRKLLTLEDKELGSGGTVKKGYYQMVVKTVAVKILDPALKDELLAEANVM
QQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIEL
VHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADEN
YYKAQTHPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMK
GSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLR
NYYYDVVN
3D structure
PDB4xg8 Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D494 A496 R498 N499 D512
Catalytic site (residue number reindexed from 1) D120 A122 R124 N125 D138
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 X8G A L377 A400 M448 M450 A451 P455 R498 L501 D512 L12 A31 M74 M76 A77 P81 R124 L127 D138 MOAD: ic50=1.9nM
PDBbind-CN: -logKd/Ki=8.72,IC50=1.9nM
BindingDB: IC50=11.1nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4xg8, PDBe:4xg8, PDBj:4xg8
PDBsum4xg8
PubMed27504936
UniProtP43405|KSYK_HUMAN Tyrosine-protein kinase SYK (Gene Name=SYK)

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