Structure of PDB 4xg1 Chain A

Receptor sequence

>4xg1A (length=393) Species: 357804 (Psychromonas ingrahamii 37)

DHFNYQNRLFVEGLPVEQVVKKTGTPAYIYSRATIERHWQAFDSKHPHLI
CYAVKANSNLAVLNLMARMGSGFDIVSVGELMRVIQAGGDPKKIVFSGVG
KTEIEISAALQANIMCFNVESISELYRINSVAKALNVKAPISIRINPNKF
GIEIEQALDVYKIASDLEFLEIKGVDCHIGSQLTIAPFIELDKLLILIDL
LAEKGITISHLDLGGGLGVPYDDEPPEPAEYMTAIINRMRLKLIFEPGRA
IMANAGVLVTKVEFLKLNDYKNFAIVDAAMNDLIRPALYSAWQNIIPLNT
DYQDGQDRPVRSYDIVGPICETGDFLGKERQLALAEGDYLVIRSTGAYGS
TMSSNYNSRCRAAEILVDGEKAFIVREREELKDLWRGEHILPI

3D structure

• PDB: 4xg1 Expression to crystallization of diaminopimelate decarboxylase from the psychrophile Psychromonas ingrahamii
• Chain: A
• Resolution: 2.5 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): K61 H200 E274
• Catalytic site (residue number reindexed from 1): K55 H178 E246
• Enzyme Commision number: 4.1.1.20: diaminopimelate decarboxylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	TME	A	S127 I128	S121 I122
BS02	LLP	A	K61 D80 S103 H200 S203 G240 E274 G276 R277 R313 Y317 Y376	K55 D74 S97 H178 S181 G216 E246 G248 R249 R285 Y289 Y348
BS03	LLP	A	C348 E349	C320 E321

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0008836 diaminopimelate decarboxylase activity
• GO:0016830 carbon-carbon lyase activity
• GO:0016831 carboxy-lyase activity
• GO:0030170 pyridoxal phosphate binding

Biological Process

• GO:0009085 lysine biosynthetic process
• GO:0009089 lysine biosynthetic process via diaminopimelate

External links

• PDB: RCSB:4xg1, PDBe:4xg1, PDBj:4xg1
• PDBsum: 4xg1
• UniProt: A1SR00