Structure of PDB 4xf3 Chain A

Receptor sequence

>4xf3A (length=186) Species: 10116 (Rattus norvegicus)

ELLKPRTLADLIRILHELFAGDEVNVEEVQAVLEAYESNPAEWALYAKFD
QYRYTRNLVDQGNGKFNLMILCWGEGHGSSIHDHTDSHCFLKLLQGNLKE
TLFDWPDKKSNEMIKKSERTLRENQCAYINDSIGLHRVENVSHTEPAVSL
HLFSPPFDTCHAFDQRTGHKNKVTMTFHSKFGIRTP

3D structure

• PDB: 4xf3 Structure-Based Insights into the Role of the Cys-Tyr Crosslink and Inhibitor Recognition by Mammalian Cysteine Dioxygenase.
• Chain: A
• Resolution: 1.55 Å

Enzymatic activity

• Enzyme Commision number: 1.13.11.20: cysteine dioxygenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FE	A	H86 H88 H140	H82 H84 H136
BS02	CYS	A	Y58 R60 L75 H86 H88 H140 H155 M179	Y54 R56 L71 H82 H84 H136 H151 M175

Gene Ontology

Molecular Function

• GO:0005506 iron ion binding
• GO:0008198 ferrous iron binding
• GO:0008270 zinc ion binding
• GO:0016151 nickel cation binding
• GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
• GO:0017172 cysteine dioxygenase activity
• GO:0046872 metal ion binding
• GO:0051213 dioxygenase activity

Biological Process

• GO:0006534 cysteine metabolic process
• GO:0007595 lactation
• GO:0019448 L-cysteine catabolic process
• GO:0033762 response to glucagon
• GO:0042412 taurine biosynthetic process
• GO:0043200 response to amino acid
• GO:0045471 response to ethanol
• GO:0046439 L-cysteine metabolic process
• GO:0051384 response to glucocorticoid
• GO:0051591 response to cAMP

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:4xf3, PDBe:4xf3, PDBj:4xf3
• PDBsum: 4xf3
• PubMed: 27477048
• UniProt: P21816|CDO1_RAT Cysteine dioxygenase type 1 (Gene Name=Cdo1)