Structure of PDB 4xey Chain A

Receptor sequence
>4xeyA (length=269) Species: 9606 (Homo sapiens) [Search protein sequence]
NYDKWEMERTDITMKHKLGGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFL
KEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQE
VNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGL
SRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIAT
YGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRP
SFAEIHQAFETMFQESSIS
3D structure
PDB4xey Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity.
ChainA
Resolution2.891 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D382 A384 R386 N387 D400 P421
Catalytic site (residue number reindexed from 1) D129 A131 R133 N134 D147 P168
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1N1 A L267 A288 K290 M309 V318 I332 T334 M337 T338 G340 L389 A399 D400 F401 L18 A35 K37 M56 V65 I79 T81 M84 T85 G87 L136 A146 D147 F148 BindingDB: IC50=3.1nM,Kd=1.2nM,EC50=0.040000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4xey, PDBe:4xey, PDBj:4xey
PDBsum4xey
PubMed25779001
UniProtP00519|ABL1_HUMAN Tyrosine-protein kinase ABL1 (Gene Name=ABL1)

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