Structure of PDB 4xev Chain A

Receptor sequence
>4xevA (length=148) Species: 9606 (Homo sapiens) [Search protein sequence]
NLDRTDDLVYLNVMELVRAVLELKNELSQLPPEGYVVVVKNVGLTLRKLI
GSVDDLLPSLPSSSRTEIEGTQKLLNKDLAELINKMRLAQQNAVTSLSEE
AKRQMLTASHTLAVDAKNLLDAVDQAKVLANLAHGGEELDALLEELER
3D structure
PDB4xev Structural Basis for the Interaction between Pyk2-FAT Domain and Leupaxin LD Repeats.
ChainA
Resolution2.0073 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V907 K911 G914 L917 R918 D925 N947 M957 R958 V36 K40 G43 L46 R47 D54 N76 M86 R87
Gene Ontology
Molecular Function
GO:0004713 protein tyrosine kinase activity
Biological Process
GO:0006468 protein phosphorylation
GO:0007172 signal complex assembly
Cellular Component
GO:0005925 focal adhesion

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4xev, PDBe:4xev, PDBj:4xev
PDBsum4xev
PubMed26866573
UniProtQ14289|FAK2_HUMAN Protein-tyrosine kinase 2-beta (Gene Name=PTK2B)

[Back to BioLiP]