Structure of PDB 4xeo Chain A

Receptor sequence
>4xeoA (length=384) Species: 9606 (Homo sapiens) [Search protein sequence]
TLTASEIRQRFIDFFKRNEHTYVHSSATIPLDDPTLLFANAGMNQFKPIF
LNTIDPSHPMAKLSRAANTQKCIRAGGKHNLDDVGKDVYHHTFFEMLGSW
SFGDYFKELACKMALELLTQEFGIPIERLYVTYFGGDEAAGLEADLECKQ
IWQNLGLDDTKILPGNMKDNFWEMGDTGPCGPCSEIHYDRIGGRDAAHLV
NQDDPNVLEIWNLVFIQYNREADGILKPLPKKSIDTGMGLERLVSVLQNK
MSNYDTDLFVPYFEAIQKGTGARPYTGKVGAEDADGIDMAYRVLADHART
ITVALADGGRPDNTGRGYVLRRILHRAVRYAHEKLNASRGFFATLVDVVV
QSLGDAFPELKKDPDMVKDIINEEEVQFLKTLSR
3D structure
PDB4xeo Crystal structure of human AlaRS catalytic domain with R329H mutation
ChainA
Resolution1.38 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.7: alanine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A5A A R77 H95 F98 M100 W176 E213 I214 N216 V218 D239 G241 G243 R74 H91 F94 M96 W172 E209 I210 N212 V214 D235 G237 G239
BS02 MG A E189 E213 E185 E209
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0004813 alanine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006419 alanyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4xeo, PDBe:4xeo, PDBj:4xeo
PDBsum4xeo
PubMed
UniProtP49588|SYAC_HUMAN Alanine--tRNA ligase, cytoplasmic (Gene Name=AARS1)

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