Structure of PDB 4xek Chain A

Receptor sequence
>4xekA (length=137) Species: 9606 (Homo sapiens) [Search protein sequence]
HMANLDRTDDLVYLNVMELVRAVLELKNELSQLPPEGYVVVVKNVGLTLR
KLIGSVDDLLPSLPSSSRTEIEGTQKLLNKDLAELINKMRLAQQNAVTSL
SEEAKRQMLTASHTLAVDAKNLLDAVDQAKVLANLAH
3D structure
PDB4xek Structural Basis for the Interaction between Pyk2-FAT Domain and Leupaxin LD Repeats.
ChainA
Resolution1.793 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K911 G914 L915 L917 R918 D925 K944 N947 L950 K43 G46 L47 L49 R50 D57 K76 N79 L82
Gene Ontology
Molecular Function
GO:0004713 protein tyrosine kinase activity
Biological Process
GO:0006468 protein phosphorylation
GO:0007172 signal complex assembly
Cellular Component
GO:0005925 focal adhesion

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4xek, PDBe:4xek, PDBj:4xek
PDBsum4xek
PubMed26866573
UniProtQ14289|FAK2_HUMAN Protein-tyrosine kinase 2-beta (Gene Name=PTK2B)

[Back to BioLiP]