Structure of PDB 4xeg Chain A

Receptor sequence
>4xegA (length=196) Species: 9606 (Homo sapiens) [Search protein sequence]
FNGVSEAELLTKTLPDILTFNLDIVIIGINPGLMAAYKGHHYPGPGNHFW
KCLFMSGLSEVQLNHMDDHTLPGKYGIGFTNMVERTTPGSKDLSSKEFRE
GGRILVQKLQKYQPRIAVFNGKCIYEIFSKEVFGVKVKNLEFGLQPHKIP
DTETLCYVMPSSSARCAQFPRAQDKVHYYIKLKDLRDQLKGIERNM
3D structure
PDB4xeg Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA.
ChainA
Resolution1.72 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N140 H151
Catalytic site (residue number reindexed from 1) N30 H41
Enzyme Commision number 3.2.2.29: thymine-DNA glycosylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A P155 K246 A274 R275 A277 P280 R281 P45 K136 A164 R165 A167 P170 R171
BS02 dna A N140 N157 S200 K201 G231 K232 C233 P270 S271 S273 A274 R275 C276 Q278 N30 N47 S90 K91 G121 K122 C123 P160 S161 S163 A164 R165 C166 Q168
Gene Ontology
Molecular Function
GO:0000700 mismatch base pair DNA N-glycosylase activity
Biological Process
GO:0006285 base-excision repair, AP site formation

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Molecular Function
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Biological Process
External links
PDB RCSB:4xeg, PDBe:4xeg, PDBj:4xeg
PDBsum4xeg
PubMed26358812
UniProtQ13569|TDG_HUMAN G/T mismatch-specific thymine DNA glycosylase (Gene Name=TDG)

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