Structure of PDB 4xee Chain A

Receptor sequence
>4xeeA (length=464) Species: 10116,10665 [Search protein sequence]
GPNSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLARKSTVHYHL
GSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYAT
ALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLF
TMGLQNRSADGTHPGGLVCTPIVDTATVKVVIQVNTFMSFLFPMLVISIL
NTVIANKLTVMVPGRVQALRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYI
SDEQWTTFLFDFYHYFYMLTNALFYASSAINPILYNLVSANFRQVFLSTL
NIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIG
RNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALIN
MVFQMGETGVAGFTNSLRMLNNKRWDEAAVNLAKSRWYNQTPNRAKRVIT
TFRTGTWDAYGSGS
3D structure
PDB4xee Structural prerequisites for G-protein activation by the neurotensin receptor.
ChainA
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) E1011 D1020
Catalytic site (residue number reindexed from 1) E310 D319
Enzyme Commision number 3.2.1.17: lysozyme.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A D54 L55 F128 H132 Y146 V224 T226 R327 R328 F331 W339 F344 Y347 Y351 D5 L6 F72 H76 Y90 V168 T170 R243 R244 F247 W255 F260 Y263 Y267
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0004930 G protein-coupled receptor activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0009253 peptidoglycan catabolic process
GO:0016998 cell wall macromolecule catabolic process
GO:0031640 killing of cells of another organism
GO:0042742 defense response to bacterium
GO:0044659 viral release from host cell by cytolysis
Cellular Component
GO:0016020 membrane
GO:0030430 host cell cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4xee, PDBe:4xee, PDBj:4xee
PDBsum4xee
PubMed26205105
UniProtP00720|ENLYS_BPT4 Endolysin (Gene Name=E);
P20789|NTR1_RAT Neurotensin receptor type 1 (Gene Name=Ntsr1)

[Back to BioLiP]