Structure of PDB 4xe5 Chain A

Receptor sequence
>4xe5A (length=995) Species: 9913 (Bos taurus) [Search protein sequence]
ERDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTTARAAEILARDGPN
ALTPPPTTPEWVKFCRQLFGGFSMLLWIGAVLCFLAYGIQAATEEEPQND
NLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKM
SINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRS
PDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLE
GGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGII
VANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKT
GTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLC
NRAVFQANQDNLPILKRAVAGDASESALLKCIEVCCGSVKEMRERYTKIV
EIPFNSTNKYQLSIHKNANAGEPRHLLVMKGAPERILDRCSSILIHGKEQ
PLDEELKDAFQNAYLELGGLGERVLGFCHLLLPDEQFPEGFQFDTDDVNF
PVDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIA
KGVGIISEGNETVEDIAARLNIPVSQVNPRDARACVVHGSDLKDMTPEQL
DDILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKA
DIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAY
TLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAE
SDIMKRQPRNPQTDKLVNERLISMAYGQIGMIQALGGFFTYFVIMAENGF
LPNHLLGIRVTWDDRWINDVEDSYGQQWTYEQRKIVEFTCHTAFFVSIVV
VQWADLVICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMGVAL
RMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGGWVEKETYY
3D structure
PDB4xe5 Isolation, crystallization and crystal structure determination of bovine kidney Na(+),K(+)-ATPase.
ChainA
Resolution3.901 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D374 D715 D719
Catalytic site (residue number reindexed from 1) D348 D689 D693
Enzyme Commision number 7.2.2.13: Na(+)/K(+)-exchanging ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A X374 T376 D715 X348 T350 D689
BS02 MG A N781 E784 D809 N755 E758 D783
BS03 OBN A Q116 E122 D126 L130 A328 F788 T802 I805 Q90 E96 D100 L104 A302 F762 T776 I779
BS04 CLR A E873 T984 P991 E847 T958 P965
BS05 CLR A W929 P983 W986 F987 F990 W903 P957 W960 F961 F964
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0005215 transporter activity
GO:0005391 P-type sodium:potassium-exchanging transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008556 P-type potassium transmembrane transporter activity
GO:0016887 ATP hydrolysis activity
GO:0046872 metal ion binding
Biological Process
GO:0002028 regulation of sodium ion transport
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0006883 intracellular sodium ion homeostasis
GO:0010248 establishment or maintenance of transmembrane electrochemical gradient
GO:0030007 intracellular potassium ion homeostasis
GO:0036376 sodium ion export across plasma membrane
GO:1902600 proton transmembrane transport
GO:1990573 potassium ion import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0005890 sodium:potassium-exchanging ATPase complex
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0030424 axon
GO:0042383 sarcolemma
GO:0042470 melanosome
GO:0042995 cell projection
GO:0045121 membrane raft

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4xe5, PDBe:4xe5, PDBj:4xe5
PDBsum4xe5
PubMed27050261
UniProtQ08DA1|AT1A1_BOVIN Sodium/potassium-transporting ATPase subunit alpha-1 (Gene Name=ATP1A1)

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