Structure of PDB 4xdk Chain A

Receptor sequence

>4xdkA (length=248) Species: 9606 (Homo sapiens)

KWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHV
CVSPQELETLIQHALDADNAGVSPIGNSHWDLGSAFFFAGTVITTIGYGN
IAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVEKVFR
KKQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVV
TLTTVGFGDFVAGGREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLS

3D structure

• PDB: 4xdk K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
• Chain: A
• Resolution: 3.6 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	K	A	I173 G174 Y175 V282 G283 F284	I96 G97 Y98 V205 G206 F207
BS02	K	A	T172 I173 G174 T281 V282 G283	T95 I96 G97 T204 V205 G206
BS03	K	A	T172 T281	T95 T204
BS04	408	A	V253 L279 T280 F316	V176 L202 T203 F233
BS05	405	A	V253 L279 T280 F316 L320	V176 L202 T203 F233 L237
BS06	405	A	I194 P198	I117 P121
BS07	408	A	I194 I197 P198	I117 I120 P121

Gene Ontology

Molecular Function

• GO:0005267 potassium channel activity

Biological Process

• GO:0071805 potassium ion transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:4xdk, PDBe:4xdk, PDBj:4xdk
• PDBsum: 4xdk
• PubMed: 25766236
• UniProt: P57789|KCNKA_HUMAN Potassium channel subfamily K member 10 (Gene Name=KCNK10)