Structure of PDB 4xcx Chain A

Receptor sequence
>4xcxA (length=216) Species: 9606 (Homo sapiens) [Search protein sequence]
QFKPPLYRQRYQFVKNLVDQHEPKKVADLGCGDTSLLRLLKVNPCIELLV
GVDINEDKLRWRGDSLAPFLGDFLKPRDLNLTITLYHGSVVERDSRLLGF
DLITCIELIEHLDSGDLARFPEVVFGYLSPSMIVISTPNSEFNPLDHKFE
WTRMEFQTWALYVANRYDYSVEFTGVGEPPGAENVGYCTQIGIFRKNQHD
QHVYKAVFTTSYPSLQ
3D structure
PDB4xcx Crystal structure of human C1ORF59 in complex with SAH
ChainA
Resolution2.84 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.386: small RNA 2'-O-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A Y36 G55 D78 I79 K83 S114 V115 I131 L133 H136 Y11 G30 D53 I54 K58 S89 V90 I106 L108 H111
Gene Ontology
Molecular Function
GO:0008171 O-methyltransferase activity
GO:0008173 RNA methyltransferase activity
Biological Process
GO:0001510 RNA methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4xcx, PDBe:4xcx, PDBj:4xcx
PDBsum4xcx
PubMed
UniProtQ5T8I9|HENMT_HUMAN Small RNA 2'-O-methyltransferase (Gene Name=HENMT1)

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