Structure of PDB 4xcu Chain A

Receptor sequence
>4xcuA (length=288) Species: 9606 (Homo sapiens) [Search protein sequence]
DLPLDPLWEFPRDRLVLGKPLGEGQVVRAEAFGMDPARPDQASTVAVKML
KDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAK
GNLREFLRARRPPGSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLA
ARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDR
VYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHC
PPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSH
3D structure
PDB4xcu First Selective Small Molecule Inhibitor of FGFR4 for the Treatment of Hepatocellular Carcinomas with an Activated FGFR4 Signaling Pathway.
ChainA
Resolution1.71 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D612 A614 R616 N617 D630 R650
Catalytic site (residue number reindexed from 1) D148 A150 R152 N153 D166 R186
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 40M A K503 E520 M524 V550 C552 A553 G556 L619 A629 D630 K48 E65 M69 V95 C97 A98 G101 L155 A165 D166 PDBbind-CN: -logKd/Ki=8.22,Kd=6nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4xcu, PDBe:4xcu, PDBj:4xcu
PDBsum4xcu
PubMed25776529
UniProtP22455|FGFR4_HUMAN Fibroblast growth factor receptor 4 (Gene Name=FGFR4)

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