Structure of PDB 4xbr Chain A

Receptor sequence
>4xbrA (length=316) Species: 9606 (Homo sapiens) [Search protein sequence]
LNRGRSRQPLVLGDNCFADLVHNQRVSHEQFRAALQLVVDPGDPRSYLDN
FIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDY
QHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLA
VLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRK
SLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKA
MKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLA
KAGPPASIVPLMRQNR
3D structure
PDB4xbr An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1
ChainA
Resolution2.94 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D440 K442 D444 S445 D458 K467 T478
Catalytic site (residue number reindexed from 1) D167 K169 D171 S172 D185 K194 T205
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A G330 S331 T332 V335 K350 M395 E396 F397 L398 L447 D458 G460 F461 G57 S58 T59 V62 K77 M122 E123 F124 L125 L174 D185 G187 F188
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4xbr, PDBe:4xbr, PDBj:4xbr
PDBsum4xbr
PubMed26607847
UniProtO96013|PAK4_HUMAN Serine/threonine-protein kinase PAK 4 (Gene Name=PAK4);
Q96EL1

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