Structure of PDB 4xar Chain A

Receptor sequence
>4xarA (length=445) Species: 9606 (Homo sapiens) [Search protein sequence]
RREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEI
NKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLLLIAGVIGGSYS
SVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAM
AEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNISIATAEKVGRSN
IRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVASD
GWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWF
RDFWEQKFQCSLRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQ
RTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPDADSIVKFDTFGDGM
GRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSRNSVPTSE
3D structure
PDB4xar Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures.
ChainA
Resolution2.26 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 40F A R64 R68 S149 Y150 S151 A172 S173 T174 Y222 D301 G302 K389 R35 R39 S98 Y99 S100 A121 S122 T123 Y171 D250 G251 K331 MOAD: Ki=107nM
PDBbind-CN: -logKd/Ki=6.97,Ki=107nM
BindingDB: EC50=38nM,Ki=93nM
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4xar, PDBe:4xar, PDBj:4xar
PDBsum4xar
PubMed25602126
UniProtQ14832|GRM3_HUMAN Metabotropic glutamate receptor 3 (Gene Name=GRM3)

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