Structure of PDB 4xaq Chain A

Receptor sequence
>4xaqA (length=443) Species: 9606 (Homo sapiens) [Search protein sequence]
AKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDR
INRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLTAITGVIGGSY
SDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKA
MAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNISVATSEKVGRA
MSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVAS
DGWGALEEVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPW
FREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHN
MHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFD
RFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPW
3D structure
PDB4xaq Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures.
ChainA
Resolution2.21 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 40F A R57 R61 S143 Y144 S145 A166 S167 T168 Y216 D295 K377 R36 R40 S99 Y100 S101 A122 S123 T124 Y172 D251 K333 MOAD: Ki=71.7nM
PDBbind-CN: -logKd/Ki=7.14,Ki=71.7nM
BindingDB: Ki=72nM,EC50=5.1nM,IC50=5.6nM
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:4xaq, PDBe:4xaq, PDBj:4xaq
PDBsum4xaq
PubMed25602126
UniProtQ14416|GRM2_HUMAN Metabotropic glutamate receptor 2 (Gene Name=GRM2)

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