Structure of PDB 4x9p Chain A

Receptor sequence
>4x9pA (length=314) Species: 9913 (Bos taurus) [Search protein sequence]
SAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQDI
AFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMTDE
DSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIVSDTSGDFRKLMVALA
KGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVCHL
QKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLY
DSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKKKYGKSLYYYIQQDTKG
DYQKALLYLCGGDD
3D structure
PDB4x9p The native structure of annexin A2 peptides in hydrophilic environment determines their anti-angiogenic effects.
ChainA
Resolution2.01 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A M278 G280 G282 D322 M253 G255 G257 D297
BS02 CA A G202 R205 K206 G207 E247 G177 R180 K181 G182 E222
BS03 CA A G50 V51 E53 G29 V30 E32
Gene Ontology
Molecular Function
GO:0001786 phosphatidylserine binding
GO:0004859 phospholipase inhibitor activity
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005544 calcium-dependent phospholipid binding
GO:0008092 cytoskeletal protein binding
Biological Process
GO:0031214 biomineral tissue development
GO:0070509 calcium ion import
GO:0070588 calcium ion transmembrane transport
GO:1905602 positive regulation of receptor-mediated endocytosis involved in cholesterol transport
Cellular Component
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0012506 vesicle membrane
GO:0016020 membrane
GO:0031982 vesicle
GO:0042470 melanosome
GO:0043231 intracellular membrane-bounded organelle
GO:0065010 extracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4x9p, PDBe:4x9p, PDBj:4x9p
PDBsum4x9p
PubMed25772737
UniProtP04272|ANXA2_BOVIN Annexin A2 (Gene Name=ANXA2)

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