Structure of PDB 4x91 Chain A

Receptor sequence
>4x91A (length=376) Species: 9606 (Homo sapiens) [Search protein sequence]
HPPVVLVPGDLGNQLEAKLDKPTVVHYLCSKKTESYFTIWLNLELLLPVI
IDCWIDNIRLVYNKTSRATQFPDGVDVRVPGFGKTFSLEFLDPSKSSVGS
YFHTMVESLVGWGYTRGEDVRGAPYDWRRAPNENGPYFLALREMIEEMYQ
LYGGPVVLVAHSMGNMYTLYFLQRQPQAWKDKYIRAFVSLGAPWGGVAKT
LRVLASGDNNRIPVIGPLKIREQQRSAVSTSWLLPYNYTWSPEKVFVQTP
TINYTLRDYRKFFQDIGFEDGWLMRQDTEGLVEATMPPGVQLHCLYGTGV
PTPDSFYYESFPDRDPKICFGDGDGTVNLKSALQCQAWQSRQEHQVLLQE
LPGSEHIEMLANATTLAYLKRVLLGP
3D structure
PDB4x91 Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase.
ChainA
Resolution2.3 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.3.1.-
3.1.1.32: phospholipase A1.
3.1.1.4: phospholipase A2.
3.1.1.5: lysophospholipase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TO4 A D13 S165 M166 V200 Q226 H359 D10 S162 M163 V197 Q223 H356
Gene Ontology
Molecular Function
GO:0004622 lysophospholipase activity
GO:0004623 phospholipase A2 activity
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0008270 zinc ion binding
GO:0008374 O-acyltransferase activity
GO:0008970 phospholipase A1 activity
GO:0016411 acylglycerol O-acyltransferase activity
GO:0016746 acyltransferase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0047499 calcium-independent phospholipase A2 activity
GO:0052739 phosphatidylserine 1-acylhydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process
GO:0006644 phospholipid metabolic process
GO:0006650 glycerophospholipid metabolic process
GO:0006651 diacylglycerol biosynthetic process
GO:0006658 phosphatidylserine metabolic process
GO:0006672 ceramide metabolic process
GO:0009062 fatty acid catabolic process
GO:0016042 lipid catabolic process
GO:0034638 phosphatidylcholine catabolic process
GO:0046338 phosphatidylethanolamine catabolic process
GO:0046470 phosphatidylcholine metabolic process
GO:0046471 phosphatidylglycerol metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005654 nucleoplasm
GO:0005764 lysosome
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular exosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4x91, PDBe:4x91, PDBj:4x91
PDBsum4x91
PubMed25727495
UniProtQ8NCC3|PAG15_HUMAN Lysosomal phospholipase A and acyltransferase (Gene Name=PLA2G15)

[Back to BioLiP]