Structure of PDB 4x8c Chain A

Receptor sequence
>4x8cA (length=554) Species: 9606 (Homo sapiens) [Search protein sequence]
QGTLIRVTPEQPTHAVCVLGTLTQLDICSSACTSFSINASPGVVVDIWPL
EVTLTMKVASGSTGDQKVQISYYPVKALLYLTGVEISLCADITRTGKVKP
KDQRTWTWGPCGQGAILLVNCDSEDLQDMSLMTLSTKTPKDFFTNHTLVL
HVARSEMDKVRVFQATRGKLSSKCSVVLGPKWPSHYLMVPGGKHNMDFYV
EALAFPDTDFPGLITLTISLLDTSNLELPEAVVFQDSVVFRVAPWIMTPN
TQPPQEVYACNEDFLKSVTTLAMKAKCKLTICDEMEIGYIQAPHKTLPVV
FDSFGYSGLDSFGNLEVSPPVTVRGKEYPLGRILFGDSCYPSNDSRQMHQ
ALQDFLSAQQVQAPVKLYSDWLSVGHVDEFLSFVPAPDRKGFRLLLASPR
SCYKLFQEQQNEGHGEALLFEKQQKIKNILSNKTLREHNSFVERCIDWNR
ELLKRELGLAESDIIDIPQLFKLKEFSKAEAFFPNMVNMLVLGKHLGIPK
PFCCLEEKVCSLLEPLGLQCTFINDFFTYHIGEVHAGTNVRRKPFSFKWW
NMVP
3D structure
PDB4x8c Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.
ChainA
Resolution3.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D350 H471 D473 A645
Catalytic site (residue number reindexed from 1) D283 H376 D378 A536
Enzyme Commision number 3.5.3.15: protein-arginine deiminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A E353 F407 G408 E411 E286 F312 G313 E316
BS02 CA A D176 D179 D125 D128
BS03 3YZ A V469 H471 D473 F583 P584 N585 N588 F634 V643 V374 H376 D378 F483 P484 N485 N488 F527 V534
Gene Ontology
Molecular Function
GO:0004668 protein-arginine deiminase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0140794 histone arginine deiminase activity
GO:0140795 histone H3R2 arginine deiminase activity
GO:0140796 histone H3R8 arginine deiminase activity
GO:0140797 histone H3R17 arginine deiminase activity
GO:0140798 histone H3R26 arginine deiminase activity
Biological Process
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0006338 chromatin remodeling
GO:0019827 stem cell population maintenance
GO:0036211 protein modification process
GO:0043687 post-translational protein modification
GO:0045087 innate immune response
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4x8c, PDBe:4x8c, PDBj:4x8c
PDBsum4x8c
PubMed25622091
UniProtQ9UM07|PADI4_HUMAN Protein-arginine deiminase type-4 (Gene Name=PADI4)

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