Structure of PDB 4x8b Chain A

Receptor sequence
>4x8bA (length=428) Species: 1078020 (Mycolicibacterium thermoresistibile ATCC 19527) [Search protein sequence]
PHRAELARQLIDARNRTLRLVDFDDAELRRQYDPLMSPLVWDLAHIGQQE
ELWLLRGGDPRRPGLLEPAVEQLYDAFVHPRASRVHLPLLSPAQARRFCA
TVRSAVLDALDRLPEDADTFAFGMVVSHEHQHDETMLQALNLRSGEPLLG
SGTALPPGRPGVAGTSVLVPGGPFVLGVDLADEPYALDNERPAHVVDVPA
FRIGRVPVTNAEWRAFIDDGGYRQRRWWSDAGWAYRCEAGLTAPQFWNPD
GTRTRFGHVEDIPPDEPVQHVTYFEAEAYAAWAGARLPTEIEWEKACAWD
PATGRRRRYPWGDAAPTAALANLGGDALRPAPVGAYPAGASACGAEQMLG
DVWEWTSSPLRPWPGFTPMIYQRYSQPFFEGAGSGDYRVLRGGSWAVAAD
ILRPSFRNWDHPIRRQIFAGVRLAWDVD
3D structure
PDB4x8b Structure of the Sulfoxide Synthase EgtB from the Ergothioneine Biosynthetic Pathway.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.99.50: gamma-glutamyl hercynylcysteine S-oxide synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE A H51 H134 H138 H45 H128 H132
BS02 CA A M354 G356 V358 E360 G398 G399 M348 G350 V352 E354 G392 G393
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016491 oxidoreductase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0044875 gamma-glutamyl hercynylcysteine sulfoxide synthase activity
GO:0046872 metal ion binding
Biological Process
GO:0052699 ergothioneine biosynthetic process
GO:0052704 ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide

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Molecular Function
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Biological Process
External links
PDB RCSB:4x8b, PDBe:4x8b, PDBj:4x8b
PDBsum4x8b
PubMed25597398
UniProtG7CFI3|EGTB_MYCT3 Hercynine oxygenase (Gene Name=egtB)

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