Structure of PDB 4x7u Chain A

Receptor sequence
>4x7uA (length=252) Species: 28040 (Micromonospora griseorubida) [Search protein sequence]
PSTGVELYLDLLKRTVSNFIYQDATHVAGLITEAAFVEEARESGEDYPTV
AHTMIGMKRLNNLQHCVESALRDGVPGDVLETGVWRGGACIFARGILKAY
DVRDRTVWVADSFQGFPKITDDDHPMDAEMNLHQYNEAVDLPTSLATVQR
NFSRYGLLDDQVRFLPGWFKDTMPTAPFERLAVLRMDGDSYGATMDVLTH
AYPRLSPGGFAIIDDYCIPACREAVHEYRDRHGISDEIVEIDRQGVYWRR
SA
3D structure
PDB4x7u Structural Basis of Substrate Specificity and Regiochemistry in the MycF/TylF Family of Sugar O-Methyltransferases.
ChainA
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.237: mycinamicin III 3''-O-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D189 D216 D217 D187 D214 D215
BS02 SAH A T55 M56 I57 E83 G85 V86 W87 D113 S114 G117 L143 W170 F171 D189 T53 M54 I55 E81 G83 V84 W85 D111 S112 G115 L141 W168 F169 D187
BS03 ZM3 A G31 Y49 L134 Y137 D191 D217 Q246 G29 Y47 L132 Y135 D189 D215 Q244
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0008168 methyltransferase activity
GO:0008171 O-methyltransferase activity
GO:0036094 small molecule binding
GO:0046872 metal ion binding
Biological Process
GO:0017000 antibiotic biosynthetic process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4x7u, PDBe:4x7u, PDBj:4x7u
PDBsum4x7u
PubMed25692963
UniProtQ49492|MYCF_MICGR Mycinamicin III 3''-O-methyltransferase (Gene Name=mycF)

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