Structure of PDB 4x7r Chain A

Receptor sequence

>4x7rA (length=493) Species: 904724 (Staphylococcus aureus subsp. aureus 21178)

MKKIFMMVHELDVNKGGMTSSMFNRSKEFYDADIPADIVTFDYKGNYDEI
IKALKKQGKMDRRTKMYNVFEYFKQISNNKHFKSNKLLYKHISERLKNTI
EIEESKGISRYFDITTRTYIAYIRKSKSEKVIDFFKDNKRIERFSFIDNK
VHMKETFNVDNKVCYQVFYDEKGYPYISRNINANNGAVGKTYVLVNKKEF
KNNLALCVYYLEKLIKDSKDSIMICDGPGSFPKMFNTNHKNAQKYGVIHV
NHHENFDDTGAFKKSEKYIIENANKINGVIVLTEAQRLDILNQFDVENIF
TISNFVKIHNAPKHFQTEKIVGHISRMVPTKRIDLLIEVAELVVKKDNAV
KFHIYGEGSVKDKIAKMIEDKNLERNVFLKGYTTTPQKCLEDFKLVVSTS
QYEGQGLSMIEAMISKRPVVAFDIKYGPSDFIEDNKNGYLIENHNINDMA
DKILQLVNNDVLAAEFGSKARENIIEKYSTESILEKWLNLFNS

3D structure

• PDB: 4x7r Structure and mechanism of Staphylococcus aureus TarM, the wall teichoic acid alpha-glycosyltransferase.
• Chain: A
• Resolution: 2.15 Å

Enzymatic activity

• Enzyme Commision number: 2.4.1.70: poly(ribitol-phosphate) alpha-N-acetylglucosaminyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZDO	A	N185 N202	N185 N202
BS02	IDS	A	N203 K233	N203 K233
BS03	SUS	A	H9 G229 S230 K233	H9 G229 S230 K233
BS04	SGN	A	K15 G16 M18 T19 R326	K15 G16 M18 T19 R326
BS05	UDP	A	G16 G17 I324 S325 R326 K331 G356 Y382 T383 P386 L407 S408 E411	G16 G17 I324 S325 R326 K331 G356 Y382 T383 P386 L407 S408 E411
BS06	3YW	A	G17 M18 H249 V250 N304 R326 E403 G404 G406	G17 M18 H249 V250 N304 R326 E403 G404 G406

Gene Ontology

Molecular Function

• GO:0016757 glycosyltransferase activity
• GO:0047269 poly(ribitol-phosphate) N-acetylglucosaminyltransferase activity

Biological Process

• GO:0019350 teichoic acid biosynthetic process
• GO:0071555 cell wall organization

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:4x7r, PDBe:4x7r, PDBj:4x7r
• PDBsum: 4x7r
• PubMed: 25624472
• UniProt: A0A0H2WWV6|TARM_STAAC Poly(ribitol-phosphate) alpha-N-acetylglucosaminyltransferase (Gene Name=tarM)