Structure of PDB 4x7l Chain A

Receptor sequence
>4x7lA (length=260) Species: 9606 (Homo sapiens) [Search protein sequence]
YISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELARE
KVMREVKALAKLEHPGIVRYFNAWLEAPPKVYLYIQMQLCRKENLKDWMN
GRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRNLKPSNIFFTMDDVV
KVGDFGLVTTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMER
VRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVF
EDLDFPGKTV
3D structure
PDB4x7l Discovery of 1H-Pyrazol-3(2H)-ones as Potent and Selective Inhibitors of Protein Kinase R-like Endoplasmic Reticulum Kinase (PERK).
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N937 K939 N942 D955 T987
Catalytic site (residue number reindexed from 1) N136 K138 N141 D154 T160
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3Z4 A A620 K622 E639 L643 V652 I886 M888 C891 G954 D955 F956 A36 K38 E55 L59 V68 I85 M87 C90 G153 D154 F155 MOAD: ic50=9nM
PDBbind-CN: -logKd/Ki=8.05,IC50=9nM
BindingDB: IC50=1300nM,EC50=200nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4x7l, PDBe:4x7l, PDBj:4x7l
PDBsum4x7l
PubMed25587754
UniProtQ9NZJ5|E2AK3_HUMAN Eukaryotic translation initiation factor 2-alpha kinase 3 (Gene Name=EIF2AK3)

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